The Carpathian Mountains in Europe are a biodiversity hot spot; harbor many relatively undisturbed ecosystems; and are still rich in seminatural, traditional landscapes. Since the fall of the Iron Curtain, the Carpathians have experienced widespread land use change, affecting biodiversity and ecosystem services. Climate change, as an additional driver, may increase the effect of such changes in the future. Based on a workshop organized by the Science for the Carpathians network, this paper reviews the current status of global change research in the Carpathians, identifies knowledge gaps, and suggests avenues for future research.